Glucose-dependent Insulinotropic Polypeptide (GIP) and Lipid Metabolism

On the Role of Glucose-dependent Insulinotropic Polypeptide, GIP, in Postprandial Metabolism in Humans

The aim of this proposal is to examine whether endogenous GIP and exogenous GIP alone and in combination with insulin affect gastric emptying (GE), appetite, energy intake, energy expenditure (EE) and plasma levels of triglycerides (TAG), free fatty acids FFA) and glycerol in man.

Inclusion Criteria:

• Informed oral and written consent
• Caucasians over the age of 18 years
• Normal 75 g oral glucose tolerance test (OGTT)
• Normal blood haemoglobin concentration
• Normal plasma lipid profile

Exclusion Criteria:

• First-degree relatives with diabetes and familial hypertriglyceridemia