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| Name | Class |
|---|---|
| Steno Diabetes Center Copenhagen | OTHER |
| University of Copenhagen | OTHER |
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Infusion of glucose-dependent insulintropic polypeptide (GIP) receptor antagonist and evaluation of effect of insulin secretion in healthy subjects.
Infusion of glucose-dependent insulintropic polypeptide (GIP) receptor antagonist and evaluation of effect of insulin secretion in healthy subjects.
Six study hyperglycemic clamps (10 mmol/l) pr. participant.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo+placebo | Placebo Comparator | Saline infusions |
|
| GIP+placebo | Active Comparator | GIP(1-42), receptor agonist |
|
| GIP+dose 1 | Experimental | GIP(1-42) and lowest dose of GIP(3-30)NH2 |
|
| GIP+dose 2 | Experimental | GIP(1-42) and dose of GIP(3-30)NH2 |
|
| GIP+dose 3 | Experimental | GIP(1-42) and dose of GIP(3-30)NH2 |
|
| GIP+dose4 | Experimental | GIP(1-42) and highest dose of GIP(3-30)NH2 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GIP receptor antagonist | Other | GIP receptor antagonist |
|
| Measure | Description | Time Frame |
|---|---|---|
| Insulin secretion | Insulin secretion rates (ISR) calculated from serum levels of C-peptide | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Metabolic Physiology | Gentofte Municipality | Copenhagen | 2900 | Denmark | ||
| Clinical Metabolic Physiology |
IPD will not be shared with other researchers unless data management agreements are signed.
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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|
| GIP receptor agonist | Other | GIP(1-42) |
|
| Saline | Other | Placebo (vehicle for infusions) |
|
| Copenhagen |
| Gentofte |
| 2900 |
| Denmark |
| D017670 |
| Sodium Compounds |