Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The elderly population have and increased risk of loss of both muscle mass and function and is therefore recommended a higher protein intake than the healthy adult population. These age-related changes in muscle function may be explained by chronic low-grade inflammation and insulin resistance. Despite the recommendation of a higher protein intake, little is known about how different protein sources may affect the metabolic health in this population. Analysis of amino acid composition show that fish can be a good protein source for humans. Many fish species are today used as feed ingredients, rather than a protein source for humans. A few studies conducted in humans and rats show that proteins from fish may improve glucose tolerance, reduce inflammation and improve lipid metabolism, indicating that proteins from fish may not only serve as a valuable nutrient but could also hold specific health promoting properties.
The present study will investigate the effects of a protein hydrolysate from blue whiting, a fish species normally used to produce fish meal for aquaculture industry, on glucose homeostasis, inflammation and serum lipids in elderly nursing home residents.
Participants receive 6g per day of protein hydrolysate from blue whiting as protein powder mixed with a non-caloric juice for 6 weeks.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blue whiting protein hydrolysate | Active Comparator | Dietary Supplement: Blue whiting protein hydrolysate 6g protein per day for 6wk |
|
| Placebo Comparator: Control | Placebo Comparator | Control group will receive non-caloric juice without protein supplementation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blue whiting protein hydrolysate | Dietary Supplement | Dietary Supplement: Blue whiting protein hydrolysate 6g protein per day for 6wk |
|
| Measure | Description | Time Frame |
|---|---|---|
| Participant compliance | Investigate the participant compliance based daily registrations by nursing home staff | 6 weeks |
| Participant dropout rate | Number of participants that completed the intervention period | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose regulation | Glucose concentration will be measured in fasting serum | 6 weeks |
| Insulin | Insulin will be measured in fasting serum/plasma |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Oddrun A Gudbrandsen, PhD | University of Bergen | Principal Investigator |
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30858985 | Result | Drotningsvik A, Oterhals A, Flesland O, Nygard O, Gudbrandsen OA. Fish protein supplementation in older nursing home residents: a randomised, double-blind, pilot study. Pilot Feasibility Stud. 2019 Feb 26;5:35. doi: 10.1186/s40814-019-0421-x. eCollection 2019. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Placebo Comparator: Control | Dietary Supplement | Control group will receive non-caloric juice without protein supplementation |
|
| 6 weeks |
| C-reactive protein in serum | C-reactive protein (a marker of inflammation) will be analysed in fasting serum | 6 weeks |
| Interleukin-6 in serum | Interleukin-6 (a marker of inflammation) will be analysed in fasting serum | 6 weeks |
| Monocyte chemoattractant protein-1 in serum | Monocyte chemoattractant protein-1 (a marker of inflammation) will be analysed in fasting serum | 6 weeks |
| ID | Term |
|---|---|
| D018908 | Muscle Weakness |
| D009133 | Muscular Atrophy |
| D006943 | Hyperglycemia |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided