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| Name | Class |
|---|---|
| Haukeland University Hospital | OTHER |
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The aim of this study is to investigate the potential effect of a marine protein hydrolysate (MPH) supplement before a meal on postprandial glucose tolerance in healthy subjects, to achieve more knowledge on this presumed beneficial, blood glucose lowering effect
To further investigate the effects of MPH in a single dose of 20 mg/kg of body weight on postprandial blood glucose, insulin and GLP-1 (as markers of glucose metabolism) in healthy, active middle-aged to elderly subjects - age 40-65 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| supplementary Marine protein hydrolysate | Experimental | 20 mg powder per kg body weight of Marine protein hydrolysate (MPH) |
|
| control | Placebo Comparator | 20 mg powder per kg body weight of casein/maltodextrin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Marine protein hydrolysate (mph) | Dietary Supplement | Marine (Cod) protein hydrolysate |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose | Postprandial glucose (mmol/L) change on each day of intervention | First sample fasting baseline, thereafter repeated samples every 20 minutes (i.e.20, 40, 60, 80, 100,120,140 minutes after baseline), last at 200 minutes after baseline. |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin | Postprandial Insulin (mIE/L) - change on each day of intervention | First sample fasting baseline, thereafter repeated samples every 20 minutes (i.e.20, 40, 60, 80, 100,120,140 minutes after baseline), last at 200 minutes after baseline |
| Hormon 1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dag Arne Lihaug Hoff, MD, PhD | Møre & Romsdal Hospital Trust, Ålesund Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ålesund Hospital, Helse Møre og Romsdal HF | Ålesund | Norway | ||||
| Haukeland University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30524707 | Result | Dale HF, Jensen C, Hausken T, Lied E, Hatlebakk JG, Bronstad I, Lihaug Hoff DA, Lied GA. Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial. J Nutr Sci. 2018 Nov 28;7:e33. doi: 10.1017/jns.2018.23. eCollection 2018. | |
| 30719283 | Result | Dale HF, Jensen C, Hausken T, Lied E, Hatlebakk JG, Bronstad I, Hoff DAL, Lied GA. Erratum: Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial - CORRIGENDUM. J Nutr Sci. 2019 Jan 18;8:e1. doi: 10.1017/jns.2018.30. eCollection 2019. |
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| ID | Term |
|---|---|
| C041626 | 5,10-dihydro-5-methylphenazine |
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A double-blind crossover trial, including two different study days, with 4-7 days wash-out (WO) period in between. The intervention implemented 20 mg of MPH per kg body weight (test material) or control (casein).
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| Control | Dietary Supplement | Maltodextrin/Casein |
|
Glucagon like peptide 1 (GLP-1) pmol/l change on each day of intervention |
| First sample fasting baseline, thereafter repeated samples (i.e.20, 40, 60, 100 minutes after baseline), last at 200 minutes after baseline |
| Visual analogue scale (VAS) | Assessed by questionnaire VAS, scale from 0-10, where 0 is minimum score and 10 is the maximum score, reported e.g. as a total score of 7. The higher the reported value is the worse outcome. | First (baseline) symptomscore (as described above) measured fasting , thereafter repeated symptom score i.e. at 20, 40 minutes after baseline, last symptom score measure at 200 minutes after baseline |
| KANE, symptom score | Assessed by questionaire KANE (family name) , scale from 0-10, where 0 is minimum score and 10 is the maximum score, reported e.g. as a total score of 7. The higher the reported value is the worse outcome. | First (baseline) symptom score (as described above) measured fasting and the next measure at 200 minutes after baseline |
| Bergen |
| Norway |
| 31692759 | Result | Dale HF, Jensen C, Hausken T, Lied E, Hatlebakk JG, Bronstad I, Hoff DAL, Lied GA. Acute effect of a cod protein hydrolysate on postprandial acylated ghrelin concentration and sensations associated with appetite in healthy subjects: a double-blind crossover trial. Food Nutr Res. 2019 Oct 22;63. doi: 10.29219/fnr.v63.3507. eCollection 2019. |