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| Name | Class |
|---|---|
| Haukeland University Hospital | OTHER |
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The aim of this study is to investigate the potential effect of different doses of MPH supplement on glucose metabolism, hunger and appetite hormones.
The potential use of marine protein hydrolysates (MPH) as a supplement with similar or better health benefits than a regular white fish meal, can be regarded both cost-effective, environmental friendly and sustainable.
The aim of this study is to investigate the potential effect of increasing/different doses of MPH supplement on glucose metabolism, hunger and appetite hormones in healthy elderly, to provide a basis for the optimalization of the daily dose for further use of MPH in clinical study protocols in elderly patients with sarcopenia, other inflammatory conditions or abnormal glucose metabolism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| marine protein hydrolysate 1234 | Experimental | Daily intake at breakfast of supplementary marine protein hydrolysate (MPH) equivalent to 10, 20, 30 or 40 mg per kg bodyweight during 1 week, followed by 3 similar cycles with other MPH dosages, with up to 7 days wash-out in between. Random sequence of arms. |
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| marine protein hydrolysate 2134 | Experimental | Daily intake at breakfast of supplementary marine protein hydrolysate (MPH) equivalent to 10, 20, 30 or 40 mg per kg bodyweight during 1 week, followed by 3 similar cycles with other MPH dosages, with up to 7 days wash-out in between. Random sequence of arms. |
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| marine protein hydrolysate 3124 | Experimental | Daily intake at breakfast of supplementary marine protein hydrolysate (MPH) equivalent to 10, 20, 30 or 40 mg per kg bodyweight during 1 week, followed by 3 similar cycles with other MPH dosages, with with up to 7 days-out in between. Random sequence of arms. |
|
| marine protein hydrolysate 4123 | Experimental | Daily intake at breakfast of supplementary marine protein hydrolysate (MPH) equivalent to 10, 20, 30 or 40 mg per kg bodyweight during 1 week, followed by 3 similar cycles with other MPH dosages, with up to 7 days wash-out in between. Random sequence of arms. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| marine protein hydrolysate 1234 | Dietary Supplement | Dietary Supplement for e.g. in this order: MPH 1600 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 800 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 2400 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 3200 mg for 7 days, than 7 days wash-out." |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose | Postprandial glucose (mmol/L) curve on day 7 in each sequence | A standardized meal, thereafter repeated measures every 20 minutes for 2 hours on day 7 in each intervention sequence |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin | Postprandial Insulin (mIE/L) - curve on day 7 in each sequence | After the standardized breakfast meal, repeated measure every 20 minutes for 2 hours, on day 7 in each intervention sequence |
| Hormon 1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dag Arne Lihaug Hoff, md phd | Helse Møre & Romsdal HF, Ålesund Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ålesund Hospital, Helse Møre og Romsdal HF | Ålesund | Norway | ||||
| Haukeland University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32042407 | Result | Jensen C, Dale HF, Hausken T, Lied E, Hatlebakk JG, Bronstad I, Lied GA, Hoff DAL. Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study. J Nutr Sci. 2019 Dec 4;8:e40. doi: 10.1017/jns.2019.37. |
| Label | URL |
|---|---|
| Related Info | View source |
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A simple open step-up design will be employed with no placebo control, but the sequence will be randomized. Both participant and investigator are blinded for the dose.
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| marine protein hydrolysate 2134 | Dietary Supplement | Dietary Supplement for e.g. in this order: MPH 3200 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 800 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 2400 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 1600 mg for 7 days, than 7 days wash-out." |
|
| marine protein hydrolysate 3124 | Dietary Supplement | Dietary Supplement for e.g. in this order: MPH 2400 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 3200 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 1600 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 800 mg for 7 days, than 7 days wash-out." |
|
| marine protein hydrolysate 4123 | Dietary Supplement | Dietary Supplement for e.g. in this order: MPH 1600 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 800 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 3200 mg for 7 days, than 7 days wash-out. Dietary Supplement: MPH 2400 mg for 7 days, than 7 days wash-out." |
|
Glucagon like peptide 1 (GLP-1) pmol/l - curve, on day 7 in each sequence
| At 6 different times point during a 2 hours period, on day 7 in each intervention sequence |
| Visual analogue scale (VAS) | Assessed by questionnaire VAS, scale from 0-10, where 0 is minimum score and 10 is the maximum score, reported e.g. as a total score of 7. The higher the reported value is the worse outcome. | Before breakfast on each study day (day 7 in each intervention sequence) |
| KANE, symptom score | Assessed by questionaire KANE (Family name of an Author) , scale from 0-10, where 0 is minimum score and 10 is the maximum score, reported e.g. as a total score of 7. The higher the reported value is the worse outcome. | Two hours after breakfast on day 1 and 7 in each intervention sequence |
| Bergen |
| Norway |