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The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.
In the intervention study normal weight participants will receive defined amounts of monosaccharides for several days. Before and after intervention parameters of intestinal barrier function will be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Monosaccharide 1 | Experimental | Participants receive standardized meals with a defined amount of monosaccharide 1. |
|
| Monosaccharide 2 | Experimental | Participants receive standardized meals with a defined amount of monosaccharide 2. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary Intervention | Other | Participants receive different monosaccharides for a defined number of days. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in parameters of intestinal barrier function | Changes in endotoxin plasma levels | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in blood pressure | Changes in systolic and diastolic blood pressure | 1 week |
| Changes in markers for glucose metabolism | Changes in fasting glucose and fasting insulin levels |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40517600 | Derived | Staltner R, Csarmann K, Geyer A, Nier A, Baumann A, Bergheim I. Fructose intake enhances lipoteichoic acid-mediated immune response in monocytes of healthy humans. Redox Biol. 2025 Sep;85:103729. doi: 10.1016/j.redox.2025.103729. Epub 2025 Jun 12. |
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| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D019446 | Endotoxemia |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
| D016470 | Bacteremia |
| D018805 | Sepsis |
| D007239 |
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| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| ID | Term |
|---|---|
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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All participants receive all interventional diets.
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| 1 week |
| Changes in blood lipid levels | Changes in triglyceride levels | 1 week |
| Changes in Uric Acid levels | Changes in Uric Acid blood levels | 1 week |
| Infections |
| D014115 | Toxemia |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |