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The aim of the study is to better understand the interplay between the intake of dietary fiber and intestinal bacteria, their metabolic activity and the effect on the intestinal barrier.
The effect of two different dietary fiber supplements is tested (arabinoxylan & ß-glucan versus inulin & fructooligosaccharides) in a randomized crossover intervention trial including healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | This arm received the arabinoxylan/ß-glucan mix first. |
|
| 2 | Experimental | This arm received the inulin/oligofructose mix first. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary fiber supplementation | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Short-chain fatty acids (SCFAs) | SCFAs in native fecal samples | Will be measured in approx. 4 weeks after study completion. |
| Measure | Description | Time Frame |
|---|---|---|
| Gut microbiome composition | 16S NGS sequencing | Will be measured in approx. 6-8 weeks after study completion. |
| Gut barrier integrity | Lipopolysaccharide-binding protein (plasma) and zonulin (feces) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephan C Bischoff, Prof., MD | University of Hohenheim, Institute of Nutritional Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Nutritional Medicine, University of Hohenheim | Stuttgart | 70599 | Germany |
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Two-armed crossover trial
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| Will be measured in approx. 4 weeks after study completion. |