Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.
In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental: Beverage 1 | Experimental | Participants receive a beverage with a defined amount of non-nutritive sweetener. |
|
| Experimental: Beverage 2 | Experimental | Participants receive a beverage with a defined amount of non-nutritive sweetener. |
|
| Experimental: Beverage 3 | Experimental | Participants receive a beverage with a defined amount of monosaccharide. |
|
| Experimental: Beverage 4 | Experimental | Participants receive a beverage with a defined amount of disaccharide. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary intervention 1 | Other | Participants receive a beverage with a defined amount of non-nutritive sweetener. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in parameters of intestinal barrier function. | Changes in plasma endotoxin levels. | 1 week |
| Changes in inflammatory markers. | Changes in IL-6 plasma levels (ng/ml). | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in blood pressure. | Changes in systolic and diastolic blood pressure | 1 week |
| Changes in markers for glucose metabolism. | Changes in fasting glucose (mg/dl) and fasting insulin levels (mU/l) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Vienna | Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40517600 | Derived | Staltner R, Csarmann K, Geyer A, Nier A, Baumann A, Bergheim I. Fructose intake enhances lipoteichoic acid-mediated immune response in monocytes of healthy humans. Redox Biol. 2025 Sep;85:103729. doi: 10.1016/j.redox.2025.103729. Epub 2025 Jun 12. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D019446 | Endotoxemia |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
| D016470 | Bacteremia |
| D018805 | Sepsis |
| D007239 |
Not provided
Not provided
All participants receive all interventional diets
Not provided
Not provided
Not provided
| Dietary Intervention 2 | Other | Participants receive a beverage with a defined amount of non-nutritive sweetener and maltodextrin. |
|
| Dietary Intervention 3 | Other | Participants receive a beverage with a defined amount of monosaccharide. |
|
| Dietary Intervention 4 | Other | Participants receive a beverage with a defined amount of disaccharide. |
|
| 1 week |
| Changes in markers for glucose metabolism. | Changes in fasting insulin levels (mU/l). | 1 week |
| Changes in blood lipid levels. | Changes in triglyceride levels. | 1 week |
| Infections |
| D014115 | Toxemia |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |