Effects of Non-calorie Sweeteners, Mono- and Disaccharides on Intestinal Barrier Function

Assessment of the Effects of Non-calorie Sweeteners on Gut Barrier and Inflammatory Markers Compared to Those of Sugars in Healthy Individuals

The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.

In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.

Inclusion Criteria:

• No known history of metabolic diseases/disorders
• BMI <25 kg/m2

Exclusion Criteria:

• Food allergies or intolerances (esp. fructose intolerance and malabsorption)
• Chronic disease of the gastrointestinal tract
• Renal insufficiency
• Taking drugs affecting lipid or glucose metabolism