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Irrigating fluid absorbed during the endoscopic surgery may alter whole blood coagulation. However, little is known about the dose-response relationships of hemodilution. The investigators have therefore performed the present study to measure the effect of a mixture of 2.7% sorbitol-0.54% mannitol solution on the coagulation pathway according to the hemodilution level using a rotational thromboelastometry (ROTEM®) tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0% dilution | Blood specimen which was diluted with 0% level using a mixture of 2.7% sorbitol-0.54% mannitol solution | ||
| 10% dilution | Blood specimen which was diluted with 10% level using a mixture of 2.7% sorbitol-0.54% mannitol solution |
| |
| 20% dilution | Blood specimen which was diluted with 20% level using a mixture of 2.7% sorbitol-0.54% mannitol solution |
| |
| 40% dilution | Blood specimen which was diluted with 40% level using a mixture of 2.7% sorbitol-0.54% mannitol solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| A mixture of 2.7% sorbitol-0.54% mannitol solution | Other | Venous blood was taken from 12 healthy volunteers and divided into four specimen bottles, which were diluted with different levels (0%, 10%, 20%, and 40%) using a mixture of 2.7% sorbitol-0.54% mannitol solution. |
| Measure | Description | Time Frame |
|---|---|---|
| FIBTEM | Fibrinolytic pathway values of rotational thromboelastometry analysis/ FIBTEM is s a proper noun which means the status of fibrinolytic coagulation pathway. | during the rotational thromboelastometry analysis/ an average of 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| INTEM | Intrinsic pathway values of rotational thromboelastometry analysis/ INTEM is a proper noun which means the status of intrinsic coagulation pathway. | during the rotational thromboelastometry analysis/ an average of 1 hour |
| EXTEM |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy volunteers
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| Name | Affiliation | Role |
|---|---|---|
| Hyo-Seok Na, PhD | Seoul National University Bundang Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
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| ID | Term |
|---|---|
| D001778 | Blood Coagulation Disorders |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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Extrinsic pathway values of rotational thromboelastometry analysis/ EXTEM is a proper noun which means the status of extrinsic coagulation pathway.
| during the rotational thromboelastometry analysis/ an average of 1 hour |