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Ondansetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of ondansetron. The investigators therefore will perform the present study to measure the effect of ondansestron on the blood coagulation pathway according to the drug concentration level using a thromboelastography test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0 ng/ml | Experimental | Blood specimen which was added 0 ul of ondansetron |
|
| 200 ng/ml | Experimental | Blood specimen which was added 0.20 ul of ondansetron |
|
| 2000 ng/ml | Experimental | Blood specimen which was added 2 ul of ondansetron |
|
| 20000 ng/ml | Experimental | Blood specimen which was added 20 ul of ondansetron |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0 ul of ondansetron | Drug | Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 nl) using ondansetron |
|
| Measure | Description | Time Frame |
|---|---|---|
| Citrated Functional Fibrinogen | Provides clot strength based on fibrinogen contribution | During the thromboelastography analysis/ an average of 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Citrated Kaolin | Normal thromboelastography | During the thromboelastography analysis/ an average of 1 hour |
| Citrated Kaolin Heparinase | To assess the effect of heparin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hyo-Seok Na, MD., PhD. | Contact | 82317877507 | hsknana@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hyo-Seok Na, MD., PhD. | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National Univ. Bundang Hospital | Recruiting | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
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| ID | Term |
|---|---|
| D001778 | Blood Coagulation Disorders |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| D017294 | Ondansetron |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| 0.2 ul of ondansetron | Drug | Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.2 ul) using ondansetron |
|
| 2 ul of ondansetron | Drug | Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (2 ul) using ondansetron |
|
| 20 ul of ondansetron | Drug | Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (20 ul) using ondansetron |
|
| During the thromboelastography analysis/ an average of 1 hour |
| Citrated Rapid Thromboelastography | A quicker assessment of clot strength, without assessment of clot initiation | During the thromboelastography analysis/ an average of 1 hour |
| Heparinized Kaolin Heparinase | To measure the platelet function | During the thromboelastography analysis/ an average of 1 hour |
| Activator F | To eliminate the platelet function | During the thromboelastography analysis/ an average of 1 hour |
| Adenosine diphosphate | To masure the drug effect | During the thromboelastography analysis/ an average of 1 hour |
| Arachidonic acid | To masure the drug effect | During the thromboelastography analysis/ an average of 1 hour |
| D002227 |
| Carbazoles |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006575 | Heterocyclic Compounds, 3-Ring |