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Palonosetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of palonosetron. The investigators therefore will perform the present study to measure the effect of palonosetron levels using thromboelastography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0 ng/ml | Experimental | Blood specimen which was added of 0 ul of palonosetron |
|
| 25 ng/ml | Experimental | Blood specimen which was added of 1 ul of palonosetron |
|
| 250 ng/ml | Experimental | Blood specimen which was added of 10 ul of palonosetron |
|
| 2500 ng/ml | Experimental | Blood specimen which was added of 100 ul of palonosetron |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0 ul of palonosetron | Drug | Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 ul) using palonosetron |
| Measure | Description | Time Frame |
|---|---|---|
| Citrated Functional Fibrinogen | Provides clot strength based on fibrinogen contribution | During the thromboelastography analysis/ an average of 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Citrated Kaolin | Normal thromboelastography | During the thromboelastography analysis/ an average of 1 hour |
| Citrated Kaolin Heparinase | To assess the effect of heparin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hyo-Seok Na, MD., PhD. | Contact | 82317877507 | hsknana@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hyo-Seok Na, MD., PhD. | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National Univ. Bundang Hospital | Recruiting | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
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| ID | Term |
|---|---|
| D001778 | Blood Coagulation Disorders |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| D000077924 | Palonosetron |
| ID | Term |
|---|---|
| D011812 | Quinuclidines |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006571 | Heterocyclic Compounds |
| D007546 | Isoquinolines |
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| 1 ul of palonosetron | Drug | Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (1 ul) using palonosetron |
|
| 10 ul of palonosetron | Drug | Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (10 ul) using palonosetron |
|
| 100 ul of palonosetron | Drug | Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (100 ul) using palonosetron |
|
| During the thromboelastography analysis/ an average of 1 hour |
| Citrated Rapid Thromboelastography | A quicker assessment of clot strength, without assessment of clot initiation | During the thromboelastography analysis/ an average of 1 hour |
| Heparinized Kaloin Heprinase | To measure the platelet function | During the thromboelastography analysis/ an average of 1 hour |
| Activator F | To elimitate the platelt function | During the thromboelastography analysis/ an average of 1 hour |
| Adenosine diphosphate | To measure the drug effect | During the thromboelastography analysis/ an average of 1 hour |
| Arachidonic acid | To measure the drug effect | During the thromboelastography analysis/ an average of 1 hour |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |