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Modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. However, studies investigating their negative effect on whole blood coagulation are missing. The aim of our study was to assess the effect of modern balanced crystalloid and colloid solutions on whole blood coagulation in vivo using rotational thromboelastometry.
Blood samples were obtained from 30 patients during knee arthroscopy before and after administration of 500 ml of modern balanced crystalloid, hydroxyethyl starch (HES) or gelatin. Rotational thromboelastometry (EXTEM, INTEM and FIBTEM tests) were performed to assess negative effect of fluid solutions on whole blood coagulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hydroxyethyl starch | Patients who received hydroxyethyl starch |
| |
| gelatin | Patients who received gelatin |
| |
| crystalloids | Patients who received crystalloids |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hydroxyethyl starch | Other | After induction to anaesthesia patients received either hydroxyethyl starch or gelatin or crystalloids |
|
| Measure | Description | Time Frame |
|---|---|---|
| thromboelastometry assessment of coagulation | ROTEM tests- clotting time in seconds, Maximal clot firmness in mm, alpha angle of in degree of following tests EXTEM, INTEM, FIBTEM | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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healthy patients undergoing knee arthroscopy
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| Name | Affiliation | Role |
|---|---|---|
| Miroslav Durila | Second Medical Faculty, Charles University and University Hospital Motol | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hopital Motol | Prague | 15006 | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31405567 | Result | Sevcikova S, Durila M, Vymazal T. [Rotational thromboelastometry assessment of ballanced crystalloid, hydroxyethyl starch and gelatin effects on coagulation: a randomized trial]. Braz J Anesthesiol. 2019 Jul-Aug;69(4):383-389. doi: 10.1016/j.bjan.2019.03.009. Epub 2019 Aug 9. |
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| ID | Term |
|---|---|
| D020141 | Hemostatic Disorders |
| D013927 | Thrombosis |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006474 | Hemorrhagic Disorders |
| D006402 | Hematologic Diseases |
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| ID | Term |
|---|---|
| D006895 | Hydroxyethyl Starch Derivatives |
| ID | Term |
|---|---|
| D013213 | Starch |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005936 | Glucans |
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| D006425 |
| Hemic and Lymphatic Diseases |
| D016769 | Embolism and Thrombosis |
| D011134 |
| Polysaccharides |