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| ID | Type | Description | Link |
|---|---|---|---|
| 15-038 | Other Identifier | CTSU |
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Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content. Raspberries are rich in phenolic and polyphenolic compounds, in particular procyanidins, ellagitannins and anthocyanins, but also phenolic acids. At present, a small number of randomized controlled trials investigating the effects of berry (poly)phenols on validated surrogate markers of cardiovascular disease risk have shown promising results. However, to date, very few human studies have specifically investigated the effects of raspberry (poly)phenols on cardiovascular function in healthy subjects. Moreover, ellagitannin-derived metabolites are believed to persist for a long period of time in the blood and urine. Therefore, the investigators will investigate the presence of plasma and urinary raspberry-derived metabolites 24h post-consumption. To the investigators knowledge, the effects of red raspberry consumption on vascular function in humans have not been investigated before. This information is necessary for the planning of long-term studies aiming to assess the potential beneficial effects of raspberries,. Therefore, this study aims to investigate the potential role of red raspberry (poly)phenols in the modulation of vascular function by monitoring changes in vascular function together with the major (poly)phenol derivatives/metabolites in plasma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 400 g frozen raspberries | Active Comparator | Red raspberry beverage Acute intake of 600 mL (1x daily) |
|
| 200 g frozen raspberries | Active Comparator | Red raspberry beverage Acute intake of 600 mL (1x daily) |
|
| Placebo control | Placebo Comparator | Raspberry deprived supplement Acute intake of 600 mL (1x daily) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 400 g frozen raspberries | Dietary Supplement | 1x daily intake of 600 mL red raspberry beverage |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline to 2 hour and 24 hour in Endothelial function | measured by flow mediated dilation (FMD) on baseline at 2 and 24 hour postconsumption | Baseline, 2 hour and 24 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline to 2 hour and 24 hour in Pulse wave velocity | measured by sphygmomanometer SphygmoCor on baseline at 2 and 24 hours postconsumption | Baseline, 2 hour and 24 hour |
| Change from baseline to 2 hour and 24 hour in Central blood pressure |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline to 2 hour and 24 hour in Polyphenol metabolites in blood plasma | measured by ultra-performance liquid chromatography/quadrupole-time-of-flight mass-spectrometry (UPLC-Q-TOF MS ) on baseline at 2 and 24 hours postconsumption | Baseline, 2 hour and 24 hour |
| Change from baseline to 2 hour and 24 hour in Polyphenol metabolites in urine |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ana Rodriguez-Mateos, PhD | Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Duesseldorf | Principal Investigator |
| Christian Heiss, MD | Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Duesseldorf | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital Duesseldorf | Düsseldorf | 40225 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29802820 | Derived | Istas G, Feliciano RP, Weber T, Garcia-Villalba R, Tomas-Barberan F, Heiss C, Rodriguez-Mateos A. Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial. Arch Biochem Biophys. 2018 Aug 1;651:43-51. doi: 10.1016/j.abb.2018.05.016. Epub 2018 May 24. |
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| 200 g frozen raspberries | Dietary Supplement | 1x daily intake of 600 mL red raspberry beverage |
|
| Placebo | Dietary Supplement | 1x daily intake of 600 mL raspberry deprived supplement |
|
measured by sphygmomanometer SphygmoCor on baseline at 2 and 24 hours postconsumption |
| Baseline, 2 hour and 24 hour |
| Peripheral blood pressure | measured by automatic sphygmomanometer on baseline at 2 and 24 hours postconsumption | Baseline, 2 h and 24 h |
| Change from baseline to 2 hour and 24 hour in Heart rate | measured by SphygmoCor on baseline at 2 and 24 hours postconsumption | Baseline, 2 hour and 24 hour |
measured by ultra-performance liquid chromatography/quadrupole-time-of-flight mass-spectrometry (UPLC-Q-TOF MS ) on baseline at 2 and 24 hours postconsumption |
| Baseline, 2 hour and 24 hour |