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| Name | Class |
|---|---|
| The Cranberry Institute | OTHER |
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Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content. Cranberries are rich in (poly)phenols compounds, in particular anthocyanins, but also phenolic acids. At present, a small number of randomized controlled trials investigating the effects of berry (poly)phenols on validated surrogate markers of cardiovascular disease risk has shown promising results. However, to date, very few human studies have specifically investigated the effects of cranberry (poly)phenols on cardiovascular function in healthy subjects. To our knowledge, no study has investigated the time and intake-dependent effect of cranberry consumption on vascular function in healthy subjects. This information is necessary for the planning of long-term studies aiming to assess the potential beneficial effects of cranberries, using optimal amounts at optimal time points. Therefore, this study aims to investigate the potential role of cranberry (poly)phenols in the modulation of vascular function by monitoring changes in vascular function together with the major (poly)phenol derivatives/metabolites in plasma and urine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cranberry 320 | Active Comparator | Dietary Supplement: Cranberry beverage with 320 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry 640 | Active Comparator | Dietary Supplement: Cranberry beverage with 640 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry 960 | Active Comparator | Dietary Supplement: Cranberry beverage with 960 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry 1280 | Active Comparator | Dietary Supplement: Cranberry beverage with 1280 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry 1600 | Active Comparator | Dietary Supplement: Cranberry beverage with 1600 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry deprived supplement |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cranberry 320 | Dietary Supplement | Dietary Supplement: Cranberry beverage with 320 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial function | measured by Flow mediated dilation at 1, 2, 4, 6 and 8 hours after intake | Baseline, on week 1, 2, 3, 4 and 5 postconsumption |
| Measure | Description | Time Frame |
|---|---|---|
| pulse wave velocity | measured by SphygmoCor at 0, 1, 2, 4, 6 and 8 hours after intake | Baseline, on week 1, 2, 3, 4 and 5 postconsumption |
| Central blood pressure | measured by SphygmoCor at 0, 1.5, 4, 6 and 8 hours after intake |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma (poly)phenol metabolites | measured by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF MS) at 0,1, 2, 4, 6, 8 and 24 hours after intake | Baseline, on week 1, 2, 3, 4 and 5 postconsumption |
| Urinary (poly)phenol metabolites |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ana Rodriguez-Mateos, PhD | Division of Cardiology, Pulmonology and Vascular Medicine | Principal Investigator |
| Christian Heiss, MD | Division of Cardiology, Pulmonology and Vascular Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital Duesseldorf | Düsseldorf | 40225 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34750642 | Derived | Mena P, Favari C, Acharjee A, Chernbumroong S, Bresciani L, Curti C, Brighenti F, Heiss C, Rodriguez-Mateos A, Del Rio D. Metabotypes of flavan-3-ol colonic metabolites after cranberry intake: elucidation and statistical approaches. Eur J Nutr. 2022 Apr;61(3):1299-1317. doi: 10.1007/s00394-021-02692-z. Epub 2021 Nov 9. |
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| Placebo Comparator |
Placebo comparator: Cranberry deprived supplement Acute intake of 500 mL (1x daily) |
|
| Cranberry 640 | Dietary Supplement | Dietary Supplement: Cranberry beverage with 640 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry 960 | Dietary Supplement | Dietary Supplement: Cranberry beverage with 960 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry 1280 | Dietary Supplement | Dietary Supplement: Cranberry beverage with 1280 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry 1600 | Dietary Supplement | Dietary Supplement: Cranberry beverage with 1600 mg of (poly)phenols Acute intake of 500 mL (1x daily) |
|
| Cranberry deprived supplement | Dietary Supplement | Cranberry deprived supplement Acute intake of 500 mL (1x daily) |
|
| Baseline, on week 1, 2, 3, 4 and 5 postconsumption |
| Peripheral blood pressure | measured by automatic sphygmomanometer at 0, 1, 2, 4, 6 and 8 hours after intake | Baseline, on week 1, 2, 3, 4 and 5 postconsumption |
| Heart Rate | measured by SphygmoCor 0, 1, 2, 4, 6 and 8 hours after intake | Baseline, on week 1, 2, 3, 4 and 5 postconsumption |
measured by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF MS) at 0, 8 and 24 hours after intake |
| Baseline, on week 1, 2, 3, 4 and 5 postconsumption |