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| Name | Class |
|---|---|
| Unity Health Toronto | OTHER |
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The purpose of this study is determine whether daily consumption of frozen red raspberries can improve the antioxidant capacity of the blood and reduce the effects of oxidative stress, dose-dependently, in a healthy adult population.
Red raspberries are an excellent source of numerous polyphenolic antioxidants. The bioactivity of these compounds have been implicated in many biological pathways and may function to reduce the risk of numerous chronic diseases. We are conducting an intervention study with frozen red raspberries on a healthy adult population in order to determine if raspberry polyphenols are bioavailable and bioactive in vivo. Twenty-four subjects (12 male and 12 female) will be recruited to participate and consume one-cup frozen red raspberries daily for two weeks, they then will randomly be assigned to consume either one, two or four cups of raspberries for another two weeks, this will be followed by four weeks of non-treatment. Blood samples and 12-hour urine collections will be taken in order to measure the concentration of raspberry polyphenols in response to treatment dose. Dose-dependent treatment effects on blood biomarkers for antioxidant capacity, oxidative stress, inflammation and other chronic disease risk factors will also be measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| one-cup | Experimental |
| |
| two-cups | Experimental |
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| four-cups | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| individually quick frozen red raspberries | Dietary Supplement | Consumption of one-cup frozen red raspberries daily for four weeks, followed by a four week period of non-treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| serum TBARS | an indicator of MDA levels, and therefore, lipid peroxidation | end of week 1, 3, 5 and 9 |
| Measure | Description | Time Frame |
|---|---|---|
| serum antioxidant capacity (AOC) | measured using the TEAC-ABTS radical cation assay | end of week 1, 3, 5 and 9 |
| serum thiols | measured using the DTNB assay, as an indicator of antioxidant levels in protein fraction |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| A V Rao, PhD | Department of Nutritional Sciences, University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital | Toronto | Ontario | M5C 2T2 | Canada |
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| individually quick frozen red raspberries | Dietary Supplement | Consumption of one-cup frozen red raspberries for two weeks, then consumption of two-cups frozen red raspberries for an additional two weeks, followed by four weeks of non-treatment. |
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| individually quick frozen red raspberries | Dietary Supplement | Consumption of one-cup frozen red raspberries for two weeks, then consumption of four-cups frozen red raspberries for an addition two weeks, followed by four weeks of non-treatment. |
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| end of week 1, 3, 5 and 9 |