E-Cigarettes and SNA

The Effects of Electronic Cigarettes on Sympathetic Nerve Activity and Oxidative Stress

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.

Inclusion Criteria:

Healthy

Exclusion Criteria:

• Cardiac disease
• Respiratory disease
• Diabetes mellitus