Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nicotine | Experimental | use of an e-cigarette filled with liquid with nicotine |
|
| no nicotine | Experimental | Use of an e-cigarette filled with liquid without nicotine |
|
| sham comparator | Sham Comparator | Use of empty e-cigarette (sham control) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| one time exposure to e-cig with nicotine | Other | one time exposure to e-cigarette vapor with nicotine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart Rate variability | Heart rate variability is a measure of autonomic tone | 10 minutes after exposure |
| Paraoxonase | plasma oxidative stress | less than 1 hour after exposure |
| Measure | Description | Time Frame |
|---|---|---|
| muscle sympathetic nerve activity | Muscle sympathetic nerve activity (MSNA) | 10 minutes after exposure |
Not provided
Inclusion Criteria:
Healthy
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCaliforniaLA | Los Angeles | California | 90095 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D014029 | Tobacco Use Disorder |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
| ID | Term |
|---|---|
| D009538 | Nicotine |
| ID | Term |
|---|---|
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011725 | Pyridines |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| One time exposure to e-cigarette without nicotine | Other | One time exposure to e-cig without nicotine |
|
| one time exposure to empty e-cigarette | Other | one time exposure to empty e-cigarette (sham control) |
|
|
| D006573 |
| Heterocyclic Compounds, 1-Ring |