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Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.
Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nicotine | Experimental | Use an e-cig filled with liquid with nicotine |
|
| no nicotine | Experimental | Use an e-cig filled with liquid without nicotine |
|
| sham comparator | Sham Comparator | Use an empty e-cigarette (sham control) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| one time exposure to e-cig with nicotine | Other | one time exposure to e-cig vapor with nicotine |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Flow mediated dilatation (FMD) | FMD is a measure of endothelial function | 10 minutes after exposure |
| Paraoxonse | plasma oxidative stress | less than 1 hour after exposure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCaliforniaLA | Los Angeles | California | 90095 | United States |
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| ID | Term |
|---|---|
| D014029 | Tobacco Use Disorder |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D009538 | Nicotine |
| ID | Term |
|---|---|
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011725 | Pyridines |
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| one time exposure to e-cig without nicotine |
| Other |
one time exposure to e-cig without nicotine |
|
| one time exposure to empty e-cig | Other | one time exposure to empty e-cig (sham control |
|
|
| D006573 |
| Heterocyclic Compounds, 1-Ring |