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| Name | Class |
|---|---|
| Tobacco Related Disease Research Program | OTHER |
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Randomized controlled trial of acute use of electronic cigarette effect on oxidative stress and inflammation.
Participants will have an acute e-cig exposure on 2 occasions 1) e-cigarette 2) sham e-cig (empty e-cig) control. Blood will be collected before and after E-cig use and analyzed for biomarkers of inflammation and oxidative stress.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| E-cig | Experimental | One time exposure to e-cig |
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| sham | Experimental | One time exposure to empty e-cig |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| e-cigarette | Other | use e-cig for 30 minutes |
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| Measure | Description | Time Frame |
|---|---|---|
| Cellular Reactive Oxygen Species, units = % fluorescence | cellular oxidative stress, including cytoplasmic and mitochondrial oxidative stress, in viable cells | within 4 hours of E-cig use |
| Measure | Description | Time Frame |
|---|---|---|
| CD 14+ Monocyte, units = % of total cells | CD 14+ Monocyte, % of total cells will be measured with antibodies and stable dye | within 4 hours of e-cig use |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCLA | Los Angeles | California | 90095 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32896211 | Derived | Kelesidis T, Tran E, Arastoo S, Lakhani K, Heymans R, Gornbein J, Middlekauff HR. Elevated Cellular Oxidative Stress in Circulating Immune Cells in Otherwise Healthy Young People Who Use Electronic Cigarettes in a Cross-Sectional Single-Center Study: Implications for Future Cardiovascular Risk. J Am Heart Assoc. 2020 Sep 15;9(18):e016983. doi: 10.1161/JAHA.120.016983. Epub 2020 Sep 8. |
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| ID | Term |
|---|---|
| D000072137 | Vaping |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D012907 | Smoking |
| D001519 | Behavior |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D066300 | Electronic Nicotine Delivery Systems |
| ID | Term |
|---|---|
| D000074602 | Smoking Devices |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
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Crossover with 2 week washout
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Code
| empty (-cigarette sham control) | Other | use empty e-cig (sham control) |
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