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Nefopam is administered as a preemptive analgesic drug to the patient undergoing breast cancer surgery. It will be evaluated whether postoperative acute and chronic pain can be reduced.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nefopam | Experimental | 20 mg nefopam in 100 ml normal saline is infused before starting operation. |
|
| Control | Placebo Comparator | 100 ml normal saline is infused before starting operation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nefopam | Drug |
| ||
| Saline |
| Measure | Description | Time Frame |
|---|---|---|
| The change of pain numerical rating score from postoperative 30 min until postoperative 3 month | Postoperative 30 min, postoperative 1 day, postoperative 1 week, postoperative 3 month |
| Measure | Description | Time Frame |
|---|---|---|
| The dose of ketorolac administered to the patient. | postoperative 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 443-607 | South Korea |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D009340 | Nefopam |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D010079 | Oxazocines |
| D001392 | Azocines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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|
| D017437 |
| Skin and Connective Tissue Diseases |
| D002712 |
| Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |