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Acute postoperative pain after video-assisted thoracoscopic surgery is very severe. Because pain after thoracic surgery prevents early recovery, and increases postoperative complications, its is important to prevent pain after video-assisted thoracoscopic surgery. In the present study, we will evaluate whether nefopam reduces pain after video-assisted thoracoscopic surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | No Intervention | Nefopam will not be administered in this group. | |
| nefopam group | Experimental | Intravenous nefopam 20 mg will be administered twice, immediately after induction of anesthesia and at the end of surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nefopam | Drug | Nefopam 20 mg is mixed to 100 mL of normal saline, and is infused intravenously over 15 minutes. 20 mg of nefopam is administered intravenously for two times, after induction and at the end of surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain after 1 hour of surgery | Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever). | 1 hour after surgery. |
| Pain after 6 hour of surgery | Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever). | 6 hours hours after surgery. |
| Pain after 12 hour of surgery | Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever). | 12 hours after surgery. |
| Pain after 24 hour of surgery | Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever). | 24 hours after surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Patient-controlled analgesia use | Fentanyl consumption administered thorough the patient-controlled analgesia machine. | 24 hours after surgery |
| Rescue analgesics | Additional analgesic use during postoperative period. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eunah Cho | Seoul | 03181 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38983158 | Derived | Ki HS, Shim JG, Choi HK, Ryu KH, Kang DY, Park J, Ahn JH, Lee SH, Cho EA. Nefopam as a multimodal analgesia in thoracoscopic surgery: a randomized controlled trial. J Thorac Dis. 2024 Jun 30;16(6):3644-3654. doi: 10.21037/jtd-24-30. Epub 2024 Jun 12. |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D009340 | Nefopam |
| ID | Term |
|---|---|
| D010079 | Oxazocines |
| D001392 | Azocines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| 24 hours after surgery. |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |