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Nefopam will be administered to the patients undergoing laparoscopic gastrectomy under the total intravenous anesthesia (TIVA).
The investigators will evaluate whether the nefopam can decrease the total amount of remifentanil administered during the operation, which will reduce the acute opioid tolerance and following consumption of fentanyl during postoperative period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Intravenous normal saline 2 ml is given slowly as a placebo before the anesthesia induction and after finishing anesthesia. |
|
| Nefopam | Experimental | Intravenous nefopam 20 mg is given slowly before the anesthesia induction and after finishing anesthesia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nefopam | Drug |
| ||
| Saline |
| Measure | Description | Time Frame |
|---|---|---|
| Change of the administered fentanyl dose from postoperative 6 h to postoperative 5 day | postoperative 6 h, postoperative 1 day, postoperative 2 day, postoperative 3 day, postoperative 5 day |
| Measure | Description | Time Frame |
|---|---|---|
| Change of the pain score from postoperative 6 h to postoperative 5 day | postoperative 6 h, postoperative 1 day, postoperative 2 day, postoperative 3 day, postoperative 5 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 443-607 | South Korea |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D009340 | Nefopam |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D010079 | Oxazocines |
| D001392 | Azocines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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|
| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D002712 |
| Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |