Effectiveness of Nefopam in Breast Cancer Surgery

Breast cancer surgery is known to cause severe acute postoperative pain, which can persist for a long time. The investigators administered nefopam preventively to patients undergoing total mastectomy or modified radical mastectomy with axillary lymph node dissection or sentinel lymph node biopsy, and evaluated its efficacy on acute and chronic postoperative pain.

Inclusion Criteria:

• Total mastectomy
• Modified radical mastectomy
• Nipple-sparing mastectomy
• American Society of Anesthesiologists physical status I or II
• Postoperative use of intravenous patient-controlled analgesia

Exclusion Criteria:

• Chronic analgesia medication
• Pregnancy
• Lactating women
• Previous operation history due to breast cancer
• Cooperation with other surgery
• Contraindication of nefopam