Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia

Many anesthesiologists use the Remifentanil for reducing a surgical pain and stabilizing a vital sign. However, this drug induce postoperative hyperalgesia. Nowadays, many studies report that low-dose Ketamine prevents the opioid-induces hyperalgesia. Nefopam,which is non-opioid analgesic, has similar mechanism with Ketamine. It will be helpful for postoperative pain control, and reduce the needs of opioid.

Inclusion Criteria:

• patient who scheduled laparoscopic cholecystectomy under general anesthesia
• American Society of Anesthesiologist(ASA) class I or II
• adult patient (age 20 - 65)

Exclusion Criteria:

• patient who has liver disease
• patient who has kidney disease
• patient who has diabetes mellitus(DM) or heart disease
• patient who takes opioid or beta-blocker
• patient who has airway disease
• patient who has allergy with the drug