Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The neuropeptide oxytocin (OXT) has been identified as a key modulator of human social behavior and it has been recently shown that OXT also contributes to pair-bonding in men. However, it is still elusive whether OXT has similar effects in women. In the present study, the investigators examine the effect of intranasal OXT on behavioral ratings of and neural responses to the male partner in female participants. In a second experiment, the modulatory effect of OXT on emotion regulation is investigated.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxytocin | Experimental | 24 IU Oxytocin (Syntocinon spray), intranasal application 30 min prior to the experiment |
|
| Placebo | Placebo Comparator | Intranasal application, containing all ingredients except for the peptide, 3 puffs per nostril |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Syntocinon-Spray | Drug | Intranasal administration of 24 IU Oxytocin |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neural response to photographs of the partner | Neural responses will be measured by using functional magnetic resonance imaging (fMRI). In the fMRI analysis the effect of oxytocin on the neural response to the photograph of the partner will be compared with placebo. | About one hour after the intranasal administration of oxytocin |
| Neural response during the regulation of food craving | Neural responses will be measured by using functional magnetic resonance imaging (fMRI). In the fMRI analysis the effect of oxytocin on the neural response to the regulation of food craving will be compared with placebo. | About one hour after the intranasal administration of oxytocin |
| Measure | Description | Time Frame |
|---|---|---|
| Attractiveness ratings of all stimuli | The effect of oxytocin on attractiveness ratings of the partner will be compared with placebo. Ratings will be obtained by using a visual analog scale. | About one hour after the intranasal administration of oxytocin |
| Arousal ratings of all stimuli |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry, University of Bonn | Bonn | 53105 | Germany |
Not provided
| Label | URL |
|---|---|
| Homepage of the research group | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The effect of oxytocin on arousal ratings of the partner will be compared with placebo. Ratings will be obtained by using a visual analog scale. |
| About one hour after the intranasal administration of oxytocin |
| Food craving ratings | The effect of oxytocin on food craving ratings will be compared with placebo. Ratings will be obtained by using a visual analog scale. | About one hour after the intranasal administration of oxytocin |