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The purpose of this study is to determine whether oxytocin influences memory of social stimuli and reaction to social stimuli. Furthermore the investigators explore the effect of oxytocin receptor (OXTR) polymorphism in terms of behavioral and neural responses to social stimuli.
The prevailing view of OXT as a key facilitator of prosocial behaviors has been highly influenced by a plethora of studies in healthy volunteers, which demonstrated increased interpersonal trust, generosity, social learning/empathy and positively biased social stimulus processing as a result of OXT treatment. However, this interpretation is challenged by observations that OXT also promotes envy and schadenfreude (gloating), ethno-centrism (including prejudice, xenophobia, and racial bias), and defensive aggression towards outsiders.We investigate the neural correlates of emotion perception and subsequent memory effects of aversive and neutral stimuli. Tthe oxytocin effect on personal space is questioned. Additionally the effect of OXTR polymorphism regarding behavioral and neural response is explored.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxytocin | Experimental | one application of 24 IU oxytocin per volunteer |
|
| Placebo | Placebo Comparator | sodium chloride solution, intranasal application, 3 puffs per nostril one application per volunteer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin | Drug | intranasal administration, 24 IU oxytocin; ; 3 puffs per nostril, each with 4 IU OXT |
|
| Measure | Description | Time Frame |
|---|---|---|
| neural correlates of emotion perception and subsequent memory effects of aversive and neutral stimuli | MRI data are analyzed using SPM8 (Wellcome Trust Centre for Neuroimaging, London, UK). In the first level analysis the following conditions are modeled: 'neutral: subsequently remembered', 'neutral: subsequently forgotten', 'aversive: subsequently remembered', and 'aversive: subsequently forgotten'. | two years |
| Measure | Description | Time Frame |
|---|---|---|
| the effect of oxytocin receptor (OXTR) polymorphism in terms of behavioral and neural responses to social stimuli | behavioral social testing, fMRI analysis using SPM8, OXTR genotyping | two years |
| The oxytocin effect on social behavior e.g. personal space is questioned |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rene Hurlemann, MSc MD PhD | Department of Psychiatry, University of Bonn, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry, University of Bonn | Bonn | 53105 | Germany |
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| Label | URL |
|---|---|
| Click here for more information about the NEMO research group | View source |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| C014635 | lactitol |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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behavioral testing e.g. personal space |
| two years |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |