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| ID | Type | Description | Link |
|---|---|---|---|
| PS_2013 | Other Grant/Funding Number | University of Bonn |
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Social touch can convey the most potent and salient of socio-emotional signals. While the hypothalamic peptide oxytocin (OXT) has been identified as a key neurochemical mediator of grooming in some other social species, its modulatory influence on human interpersonal touch is unknown. The investigators expect that OXT augments the hedonic value of touch and that this behavioral effect is paralleled at the neural level by an increased response in brain areas mediating rewarding aspects of social touch.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxytocin | Experimental | 24 IU Oxytocin, intranasal application 30 min prior to the experiment |
|
| Placebo | Placebo Comparator | intranasal application, sodium chloride solution, 3 puffs per nostril |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Drug | intranasal application, sodium chloride solution, 3 puffs per nostril |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Pleasantness ratings of social touch | After each trial, subjects are asked to use a visual analog scale to rate the pleasantness of the administered touch. | 30 minutes after the nasal spray administration |
| Blood-oxygen-level dependent signal in response to social touch | By using functional magnetic resonance imaging we want to examine oxytocin's effects on the neural correlates (BOLD signal) of social touch. | 30 minutes after the nasal spray administration |
| Measure | Description | Time Frame |
|---|---|---|
| Questionnaire measurement of mood (PANAS) and anxiety (STAI). | 15 minutes before the nasal spray administration and (on average) 10 minutes after the fMRI experiment |
| Measure | Description | Time Frame |
|---|---|---|
| Saliva oxytocin concentrations | 15 minutes before the nasal spray administration and (on average) 10 minutes after the fMRI experiment |
Inclusion Criteria:
Healthy male volunteers
Exclusion Criteria:
Current or past psychiatric disease Current or past physical illness Psychoactive medication Tobacco smokers
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry, University of Bonn | Bonn | North Rhine-Westphalia | 53105 | Germany |
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| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Oxytocin |
| Drug |
24 IU Oxytocin, intranasal application 45 min prior to the experiment |
|
|
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |