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| ID | Type | Description | Link |
|---|---|---|---|
| OXT-151/12 | Other Grant/Funding Number | HU1302/2-2 and NEMO |
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Mounting evidence indicates that the intranasal administration of the neuropeptide oxytocin has prosocial effects. However, the neural substrates of these effects are still unclear. The investigators hypothesized that a single dose administration of oxytocin should increase empathogenic and affiliative responses and that these effects are mediated by an increased insula activity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxytocin | Experimental | 24 IU Oxytocin, intranasal application 45 min prior to the experiment |
|
| Placebo | Placebo Comparator | Intranasal application, sodium chloride solution, 3 puffs per nostril |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin | Drug | 24 IU; 3 puffs per nostril, each with 4 IU OXT |
|
| Measure | Description | Time Frame |
|---|---|---|
| Empathy ratings and their neural correlates | All subjects are scanned while they view emotional and neutral faces and rate their empathy for these stimuli. | About one hour after the intranasal administration of oxytocin |
| Measure | Description | Time Frame |
|---|---|---|
| Neural correlates of pair-bonding | All subjects are scanned while they view a picture of their mate and and an unknown female. | About one hour after the intranasal administration of oxytocin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| René Hurlemann, MD PhD M.Sc. | Department of Psychiatry University of Bonn | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry, University of Bonn | Bonn | North Rhine-Westphalia | 53105 | Germany |
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| Label | URL |
|---|---|
| NEMO research group | View source |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| C014635 | lactitol |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Placebo | Drug |
|
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |