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Many devices are available for nebulising drug solution during invasive mechanical ventilation. Vibrating-mesh nebulizers ensure the highest lung deposition output. A recent international survey on aerosol therapy during mechanical ventilation (Ehrmann et al. 2013) reported that jet nebulizers remained the mostly used.
The aim of this study is to compare lung deposition of a radiolabeled administered with both nebulizers during invasive mechanical ventilation by planar scintigraphy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nebulization with a vibrating-mesh nebulizer | Active Comparator | Nebulization performed with a vibrating-mesh nebulizer |
|
| Nebulization with a jet nebulizer | Active Comparator | Nebulization performed with a jet nebulizer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| technetium-99m - Diethylenetriaminepentaacetic acid | Drug |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary deposition | Immediately after nebulization by imaging assessment, an expected average of 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Penetration index | Immediately after nebulization by imaging assessment, an expected average of 30 minutes | |
| Mechanical ventilation settings | During nebulisation time, an expected average of 15 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre-François Laterre | Head of Intensive Care Unit, Cliniques Universitaires Saint-Luc | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques Universitaires Saint-Luc | Brussels | Belgium |
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| Vibrating-mesh nebulizer |
| Device |
|
| Jet Nebulizer | Device |
|
| Planar scintigraphy | Other |
|
| Preoperative spirometry | Other |
|
| Lung function | Preoperative assessment, the day before inclusion |