Study of the Aerosol Deposition With Vented and Unvented Jet Nebulizer in Healthy Subjets

Open-vent jet nebulizers are frequently used to promote drug lung deposition but their clinical efficacy and indications are not clear.

Our study aimed to compare inhaled mass, and lung deposition of amikacin by using a jet nebulizer (Sidestream) under two different configurations: vented and unvented coupled to a 110 ml corrugated piece of tubing.

Inclusion Criteria:

• Healthy Volunteers between 18 and 60 years old

Exclusion Criteria:

• Smokers
• Pathological spirometry
• History of treatment with aminoglygosides 1 month prior the study
• Known allergy to aminoglycosydes
• Any lung pathology or history of lung surgery