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Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.
On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.
Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aeroneb Solo | Active Comparator | Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula. |
|
| Standard Jet Nebulizer | Active Comparator | Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Technetium-99m - Diethylenetriaminepentaacetic acid | Drug | 99mTc-DTPA solution placed on the nebulizer reservoir |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary deposition | Single photon emission tomography combined with a CT-scan | Immediately after nebulization by imaging technique, expected average of 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Three-dimensional penetration index | immediately after the nebulization by imaging assessment, expected average of 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Spirometry | Baseline |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium |
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| Aeroneb Solo | Device |
|
| Jet Nebulizer | Device |
|
| Single photon emission computed tomography | Other | Imaging technique to investigate lung aerosol distribution |
|
| Spirometry | Other | FEV1, FVC assessment |
|