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Aeroneb Solo Adapter is a vibrating-mesh nebulizer Aeroneb Solo combined to a spacer specifically designed for spontaneously breathing patients. This device has not been investigated in vivo yet.
It's known that using a spacer during nebulization improves aerosol delivery. We hypothetized that lung deposition could be highly increased with the Aeroneb Solo Adapter in comparison to a standard jet nebulizer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aeroneb Solo Adapter | Active Comparator | Subjects inhaled radiolabelled aerosol via the Aeroneb Solo Adapter |
|
| Standard Jet Nebulizer | Active Comparator | Subjects inhaled radiolabelled aerosol via a standard jet nebulizer, the Opti-Mist Plus Nebulizer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Technetium-99m - Diethylenetriaminepentaacetic acid | Drug | Solution placed on the nebulizer reservoir |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary deposition | Planar scintigraphy and single photon emission computed tomography as imaging techiques | immediately after nebulization by imaging assessment, an expected average of 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Three-dimensional penetration index | Single photon emission computed tomography as imaging technique | immediately after the nebulization by imaging assessment, expected average of 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Spirometry | Baseline |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27822851 | Derived | Dugernier J, Hesse M, Vanbever R, Depoortere V, Roeseler J, Michotte JB, Laterre PF, Jamar F, Reychler G. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. Pharm Res. 2017 Feb;34(2):290-300. doi: 10.1007/s11095-016-2061-7. Epub 2016 Nov 7. |
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| Aeroneb Solo Adapter | Device | Nebulizer |
|
| Opti-Mist Plus Nebulizer | Device | Standard jet nebulizer |
|
| Planar scintigraphy | Other | Imaging technique to investigate whole lung deposition |
|
| Single photon emission computed tomography | Other | Imaging technique to investigate regional pulmonary deposition |
|
| Spirometry | Other | FEV1, FVC assessment |
|
| ID | Term |
|---|---|
| D009330 | Nebulizers and Vaporizers |
| ID | Term |
|---|---|
| D004864 | Equipment and Supplies |
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