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Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition.
The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nebulization during pressure support ventilation | Active Comparator | Patients ventilated in pressure support mode during nebulization |
|
| Nebulization during volume assist control mode | Active Comparator | Patients ventilated in volume assist control mode during nebulization |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| technetium-99m - Diethylenetriaminepentaacetic acid | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary deposition | Immediately after nebulization by imaging assessment, an expected average of 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Penetration index | Immediately after nebulization by imaging assessment, an expected average of 30 minutes | |
| Mechanical ventilation settings | During nebulisation time, an expected average of 15 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre-François Laterre | Head of Intensive Care Unit, Cliniques Universitaires Saint-Luc | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27447788 | Derived | Dugernier J, Reychler G, Wittebole X, Roeseler J, Depoortere V, Sottiaux T, Michotte JB, Vanbever R, Dugernier T, Goffette P, Docquier MA, Raftopoulos C, Hantson P, Jamar F, Laterre PF. Aerosol delivery with two ventilation modes during mechanical ventilation: a randomized study. Ann Intensive Care. 2016 Dec;6(1):73. doi: 10.1186/s13613-016-0169-x. Epub 2016 Jul 22. |
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| Vibrating-mesh nebulizer | Device |
|
| Gamma scintigraphy | Other |
|
| Preoperative spirometry | Other |
|
| Lung function | Preoperative assessment, the day before inclusion |