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To compare lung deposition of amikacin in two settings: spontaneously breathing through a tracheostomy cannula and through the mouth.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nebulization through the tracheostomy | Experimental | Each subjects received two nebulization sessions. The first session was performed prior the tracheostomy removal (through the tracheostomy) and the second one when the when the tracheostome was totally scared (through the mouth) |
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| Nebulization through the mouth | Active Comparator | Each subjects received two nebulization sessions. The first session was performed prior the tracheostomy removal (through the tracheostomy) and the second one when the when the tracheostome was totally scared (through the mouth) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nebulization through the tracheostomy | Other | Each subject received two nebulization sessions under spontaneous breathing in a sitting position. The first session was performed prior to tracheostomy removal. During the first nebulization, subjects inhaled the aerosol through the tracheostomy, cuff inflated and inner cannula removed. |
| Measure | Description | Time Frame |
|---|---|---|
| Amikacin urinary drug concentration | At each micturition during 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium |
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| Nebulization through the mouth | Other | Each subject received two nebulization sessions under spontaneous breathing in a sitting position. The second nebulization was performed when the tracheostome was totally scarred. During the second nebulization, subjects inhaled the aerosol a mouth piece and wore a nose clip. |
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