The Effect of Dietary Fiber-enriched Cereals on Glycemic Control and Secretion of Gut Hormones

The Effect of Dietary Fiber-enriched Cereals on Glycemic Control and Secretion of Gut Hormones

The aim of this study is to assess whether dietary fiber-enriched cereals effect on postprandial glucose levels and plasma glucagon-like peptide 1 (GLP-1) and/or glucose-dependent insulinotropic polypeptide (GIP) concentration in patients with type 2 diabetes mellitus.

Fifteen subjects with type 2 diabetes mellitus will be provided with study meals based on either dietary fiber-enriched cereals or conventional cereals upon two separate admissions in a cross-over fashion. The study meals will be provided at 6 p.m. and 10 p.m. on the day of admission, and 8 a.m. on the next day. A hamburger with coke as mixed meal will be given for lunch at noon on the second day. Blood sampling will be done every 30 minutes from 8 a.m. to 4 p.m. on the second day. The plasma levels of glucose, GLP-1, GIP, insulin, glucagon, and free fatty acid will be measured.

Inclusion Criteria:

• type 2 diabetes mellitus
• HbA1c 6.5~8.5%
• on life style modification or metformin monotherapy at the time of screening

Exclusion Criteria:

• on sulfonylurea or insulin therapy at the time of screening
• allergy to wheat, flour, other cereals or nuts
• lactose intolerance
• pregnancy / lactation