Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies

Etude de la mémoire Avant et après Chirurgie d'Une épilepsie Partielle pharmacorésistante : Bases Neurobiologiques, Applications Cliniques

This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.

Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.

Inclusion Criteria:

• Patients with drug-resistant epilepsy
• Age of 18 years or more
• Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
• Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
• Covered by a social security system
• Signing of consent form

Exclusion Criteria:

• Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
• Refusal to consent form
• Contraindications to MRI
• Pregnancy
• Refusal to be informed in the case of detection of an abnormality during the experiment