Drug-resistant focal epilepsy (DRFE) is frequently associated with complications of varying severity that impair patient's quality of life. Among these complications, cognitive disturbances and especially episodic memory difficulties, play a determinant part. Episodic memory can be defined as a function that allows the mental reconstruction of a past life episode, through complex associative mechanisms that link the vivid experience to its context of occurrence, called encoding context. It is a dynamic cognitive function, which calls on a widely distributed cerebral network, mainly involving the medial temporal lobe, particularly the hippocampus. Epilepsy could have a specific impact on this crucial network, disrupting the binding mechanisms between the experienced events and their encoding context, which are essential for efficient memory. Although patients with DRFE frequently demonstrate memory impairment as assessed by standardised neuropsychological tests, it only imperfectly reflects their difficulties. As a matter of fact, despite a subjective memory complaint, about 20% have no memory impairment on these tests, resulting from a phenomenon called accelerated long-term forgetting (ALF). ALF is indeed characterised by normal performance on standardised neuropsychological tests involving retention delays of 20-30 minutes, but disabling memory complaint and abnormally marked forgetting within hours or days that follow the learning period. This phenomenon is widely described at the conceptual level, but remains difficult to measure in daily practice, at least partly due to methodological limits. Thus, the validated tools available in clinical routine are poorly adapted to the complexity and the associative dimension of memory networks. There is therefore a clinical need for a specific assessment tool that would be able to detect ALF, in order to better quantify it and to enable the appropriate care of patients suffering from DRFE. The aim of the EPIMNESIE study is to evaluate the diagnostic capacity of a behavioural associative memory task, based on the analysis of encoding and consolidation mechanisms, in order to measure ALF. In this prospective study, 40 patients with DRFE and 40 healthy subjects will be proposed to complete a new associative memory task involving a learning phase and two recall sessions which will take place at 30 minutes and 72 hours after the learning phase.

Epilepsy group :

Inclusion Criteria:

• Adult (≥ 18 years old) suffering from drug-resistant focal epilepsy
• Patient who recently benefit from a comprehensive neuropsychological assessment (≤2 years)
• Patient presenting a subjective memory complaint consistent with an ALF
• Patient who obtained normal performance at memory tests during the comprehensive neuropsychological assessment
• Patient who gave its written informed consent to participate to the study
• Patient with corrected or non-corrected visual acuity allowing fluid reading on a computer screen
• Patient affiliated to the French health care system

Exclusion Criteria:

• Patient with impaired reading or understanding
• Patient suffering from a major depressive syndrome (score >15 on the French version of the Neurological Disorders Depression Inventory for Epilepsy - NDDIE)
• Patient who have undergone epilepsy surgery
• Patient who presented a seizure within the hour preceding the first test session
• Protected major
• Pregnant or breastfeeding woman

Control group

Inclusion Criteria:

• Adult (≥ 18 years old) without any neurological or psychiatric history
• Adult who gave its written informed consent to participate to the study
• Adult with corrected or non-corrected visual acuity allowing fluid reading on a computer screen
• Adult with normal scores on the Montreal Cognitive Assessment (MoCA) and the Matrix reasoning sub-test of the Fourth Edition Wechsler Adult Intelligence Scale (MoCA ≥ 27/30, Matrix reasoning >5)

Exclusion Criteria:

• Adult suffering from a depressive syndrome or a significative anxiety (score ≥ 8 in each dimension of the French version of the Hospital Anxiety and Depression Scale - HADS)
• Adult presenting a spontaneous subjective memory complaint
• Protected major
• Pregnant or breastfeeding woman