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| Name | Class |
|---|---|
| Laboratoire de Psychologie et NeuroCognition | OTHER |
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Exploring the reorganization (plasticity) of neuroanatomic networks associated with language and memory in patients with left (or dominant hemisphere) temporal lobe epilepsy using functional MRI (fMRI)
The purpose of this study is to explore the reorganization of neuroanatomic networks associated with language and memory in adult patients with temporal lobe epilepsy (ELT). By using functional MRI, patients will be examined before and after surgery. Cerebral plasticity, defined in terms of intrinsic variables such as the topography of the activated regions, will be explored according to some extrinsic factors such as the age at onset of crises (before or after 5-6 years), whether or not Hippocampal sclerosis, hemispheric predominance of language (left or right).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| epileptic patients | Experimental | 2 functional MRI (pre and post resective surgery) with memory and language tasks |
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| Healthy volunteers | Other | 1 functional MRI with memory and language tasks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| functional MRI | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| neuronal reorganization exploration in language and memory area thanks to functionnal MRI | fMRI exam before and after resection surgery of epileptogenic area: assess (plasticity) of neuroanatomic networks associated with language and memory - examined before and after surgery | one hour for each exam |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexandre KRAINIK, PhD | University Hospital, Grenoble | Principal Investigator |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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2 arms : epileptic patient and healthy volonteers
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