Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy

Feasibility Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy, Before and After Surgery. Evaluation by Functional and Anatomic Neuroimaging

This study consist of define anatomo-functional reorganization (plasticity) profiles for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.

For that, patients will have 2 MRI examinations, one before surgery and the second, between 3 and 8 months after surgery.

Inclusion Criteria:

• Patients with diagnosis of pharmaco-resistant focal epilepsy
• Patient candidate for surgery to resect the epileptogenic zone
• Patients affiliated to a social security scheme or beneficiaries of such a scheme
• Patients with French as their mother tongue
• Patients who have given signed informed consent before performing any procedure related to the study.

Exclusion Criteria:

• Contraindication to performing an MRI:
• Intellectual disability objectified by a Mini Mental Score (MMS) score <24 in the year preceding inclusion,
• Existence of a severe condition in general: cardiac, respiratory, hematological, renal, hepatic, cancerous,
• Participation in other research protocols underway with exclusion period or in the previous week,
• Persons referred to in Articles L1121-5 to L1121-8 of the Public Health Code.