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| ID | Type | Description | Link |
|---|---|---|---|
| 2020-A00445-34 | Registry Identifier | ID RCB |
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The main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation.
The recordings will also be used to study physiological mechanisms like sleep and different cognitive functions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Macro-microelectrode implantation | Experimental | Implantation of macro-micro electrodes of the Adtech Benkhe-Fried type in epileptic patients who are undergoing evaluation with intracranial EEG electrodes |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intracranial macro-microelectrode recording | Device | Additionnally to clinical macroelectrodes, Benkhe-Fried depth macro-microelectrodes will be implanted and recorded during the pre-surgical investigation of epileptic patients |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of single unit changes at seizure emergence | In order to identify biomarkers of epileptic seizures we will study single neuron activities (firing rate) using spike sorting at different time periods (before, during and after seizures and during interictal periods) We expect to observe significant changes in firing rate across the different time periods. | Whole duration of the clinical inverstigation, until 4 weeks |
| Identification of local field potential (LFP) changes at seizure emergence | In order to identify biomarkers of epileptic seizures we will study LFP power using time frequency analysis at different time periods (before, during and after seizures and during interictal periods) We expect to observe significant changes in LFP power across the different time periods. | Whole duration of the clinical inverstigation, until 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of single unit activity before seizure according to brain localization | We will compare firing rate before seizure according to brain regions (anatomy and involvement in the seizure onset zone) | Whole duration ofthe clinical inverstigation, until 4 weeks |
| Identification of single unit changes during physiological brain activity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vincent Navarro | Contact | 01 42 16 19 40 | vincent.navarro@aphp.fr | |
| Virginie Lambrecq | Contact | 0142161572 | Virginie.lambrecq@aphp.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital de la Salpêtrière | Recruiting | Paris | 7501F3 | France |
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We will compare firing rates during resting states and stimulus induced states. We expect to observe significant changes in firing rate between states. |
| Whole duration ofthe clinical inverstigation, until 4 weeks |
| Identification of LFP power changes during physiological brain activity | We will compare LFP power during resting states and stimulus induced states. We expect to observe significant changes in LFP power between states. | Whole duration ofthe clinical inverstigation, until 4 weeks |
| Multilevel study of brain activity | We will look for correlation between firing rates and LFP power changes. | Whole duration ofthe clinical inverstigation, until 4 weeks |
| ID | Term |
|---|---|
| D004828 | Epilepsies, Partial |
| D012640 | Seizures |
| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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