Brain Activity in Epilepsy

Study of Brain Activity in Candidates for Epilepsy Surgery

Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.

The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function.

The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level.

Scientific objectives of the current project:

• To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
• To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
• Identifying pivotal regions for BMI applications and developing online decoding algorithms.
• Comparing neural recordings to fMRI activity

Inclusion Criteria:

• Age ≥18 yo
• Epilepsy patients undergoing intracranial electrode placement.
• Able to understand the procedure involved and to consent.

Exclusion Criteria:

• Age < 18 yo
• Pregnancy