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The purpose of this study is to investigate the influence of the laparoscopic and open left hemihepatectomy on acute surgical trauma and stress response.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laparoscopic left hemihepatectomy group | Active Comparator | Group of patients that are operated with laparoscopic left hemihepatectomy |
|
| Open left hemihepatectomy | Active Comparator | Group of patients operated with open left hemihepatectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic left hemihepatectomy | Procedure | participants will be performed with laparoscopic left hepatectomy using laparoscopic instruments |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma C-reactive protein (CRP) level | CRP will be tested before operation, 3,12,24 hours and 3,5,7 days after operation | up to 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory response markers including interleukin-6, interleukin-10 concentrations and tumor necrosis factor α level in serum | interleukin-6 and interleukin-10 will be tested before operation, 3,12,24 hours and 3,5,7 days after operation | up to 7 days |
| Oxidative stress status including plasma malondialdehyde level and total antioxidant capacity |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital costs | Participants will be followed for the duration of hospital stay, an expected average of 10 days |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of General Surgery, Institute of Minimally Invasive Surgery, Sir Run Run Shaw Hospital | Hangzhou | Zhejiang | China |
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| Open left hemihepatectomy | Procedure | participants will be performed with traditional open left hepatectomy using laparotomic instruments |
|
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plasma malondialdehyde level and total antioxidant capacity will be tested before operation, 3,12,24 hours and 3,5,7 days after operation |
| up to 7 days |
| Immune status including white blood cell count and human leukocyte antigen DR (HLA-DR) expression | white blood cell count and human leukocyte antigen DR (HLA-DR) expression will be tested before operation, 3,12,24 hours and 3,5,7 days after operation | up to 7 days |
| Status of insulin resistant | Status of insulin resistant will be tested before operation, 3,12,24 hours and 3,5,7 days after operation | up to 7 days |
| Systemic inflammatory response syndrome | up to 7 days |
| Status of hepatic cell apoptosis including hematoxylin and eosin (HE) staining, immunohistochemistry staining and caspase-3 expression | 24 hours |
| Time to functional recovery | Participants will be followed for the duration of hospital stay, an expected average of 7 days |
| Postoperative hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 8 days |
| Morbidity and mortality | up to 1 month |
| Quality of life | up to 1 month |
| Intraoperative parameters including operation time, pneumoperitoneum time, liver resection time, intraoperative estimated blood loss,transfusion | participants will be followed for the duration of operation, an expected average of 120 minutes |