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The purpose of this study is to investigate the clinical value of laparoscopic liver resection in the treatment of hepatocellular carcinoma by assessing its Surgical and oncologic outcomes comparing with open liver resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laparoscopic liver resection group | Active Comparator |
| |
| Open liver resection | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic liver resection | Procedure | participants will be performed with laparoscopic hepatectomy using laparoscopic instruments |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total survival time and disease free survival time | up to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Surgical margins | 7 days | |
| Time to functional recovery | participants will be followed for the duration of hospital stay, an expected average of 6 days | |
| Postoperative hospital stay |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital costs | participants will be followed for the duration of hospital stay, an expected average of 9 days |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiujun Cai, MD | Contact | 0086-0571-86006605 | caixiujunzju@yahoo.com.cn |
| Name | Affiliation | Role |
|---|---|---|
| Xiujun Cai, MD | Sir Run Run Shaw Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of General Surgery, Institute of Minimally Invasive Surgery, Sir Run Run Shaw Hospital | Recruiting | Hangzhou | Zhejiang | 310000 | China |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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|
| Open liver resection | Procedure | participants will be performed with open hepatectomy using laparotomic instruments |
|
|
| participants will be followed for the duration of hospital stay, an expected average of 7 days |
| Morbidity and mortality | up to 3 months |
| Quality of life | up to 1 year |
| Intraoperative parameters including operation time,pneumoperitoneum time, liver resection time, estimated blood loss,transfusion, as well as number,size and location of the tumor | participants will be followed for the duration of operation, an expected average of 90 min |
| Regulatory T cells and associated cytokines in peripheral blood | Regulatory T cells and associated cytokines in peripheral blood will be tested 1day before operation,5 days, 3,6 months and 1,3,5 years after operation | up to 5 years |
| Regulatory T cells and associated cytokines in liver cancer、para-carcinoma and healthy liver tissue | 7 days |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |