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Laparoscopic left sectionectomy has been associated with shorter hospital stay and reduced overall morbidity compared with open left sectionectomy. Strong evidence has not, however, been provided.
The application of laparoscopic technology to liver surgery has been developing rapidly, yet very few studies have been conducted to compare the outcomes between open and laparoscopic liver resections. So little is known about their advantages and disadvantages. The aim of this prospective randomized study is to compare the outcomes between laparoscopic and open liver resection in treatment of hepatolithiasis within the left lobes within an enhanced recovery after surgery programme.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| open left hepatic sectionectomy | Active Comparator | patients undergoing open left hepatic sectionectomy within an enhanced recovery after surgery programme |
|
| laparoscopic hepatic sectionectomy | Experimental | patients undergoing a laparoscopic left hepatic sectionectomy within an enhanced recovery after surgery programme |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| laparoscopic hepatic sectionectomy | Procedure | patients undergoing a laparoscopic left hepatic sectionectomy within an enhanced recovery after surgery programme |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hospital duration after operation (days) | the length of hospital stay | up to 30 days after liver resection |
| Measure | Description | Time Frame |
|---|---|---|
| Readmission percentage | Readmission percentage during one year follow-up | up to 30 days after liver resection |
| Total morbidity | According to The Clavien-Dindo Classification, https://www.assessurgery.com/clavien-dindo-classification/ |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| hui s hou, master | Contact | +8615856943673 | +8615856943673 | aydpanshubo@126.com |
| shubo s pan, Doctor | Contact | +8615856943673 | +8615856943673 | aydpanshubo@126.com |
| Name | Affiliation | Role |
|---|---|---|
| hui hou, master | The Second Hospital of Anhui Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The second hospital of Anhui Medical University, | Recruiting | Hefei | Anhui | 230061 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38383461 | Derived | Pan SB, Wu CL, Zhou DC, Xiong QR, Geng XP, Hou H. Total laparoscopic partial hepatectomy versus open partial hepatectomy for primary left-sided hepatolithiasis: study protocol for a randomized controlled trial. Trials. 2024 Feb 22;25(1):137. doi: 10.1186/s13063-023-07476-w. |
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|
| open left hepatic sectionectomy | Procedure | patients undergoing open left hepatic sectionectomy within an enhanced recovery after surgery programme |
|
| up to 1 year after liver resection |
| Composite endpoint of liver surgery specific morbidity | Parameter composed of a combination of procedure-specific complications and considered as a single, dichotomous outcome: operative mortality, intra-abdominal haemorrhage, ascites, bile leakage, intra-abdominal abscess and postresectional liver failure. These components, which are all specific to liver surgery and have substantial clinical relevance, reflect Dindo grade 3-5 complications. A composite score of 1 (=failure) will reflect the occurrence of at least one of the above liver specific complications, consequently a score of 0 (=success) will be assigned if none occur. | up to 1 year after liver resection |
| Hospital and societal costs | The economic evaluation will include a cost-utility analysis from a Dutch societal perspective. The incremental costs per Quality Adjusted Life Year (QALY) gained will be based on utility scores from the EQ-5D. All hospital expenses (direct and indirect) related to both interventions will be monitored. In addition, a cost questionnaire offered at the regular follow-up consultation (3, 6 and 12 months) will help us to assess the societal and individual costs outside health care relating to patients' absence, impaired mobility, work or normal daily activities. | up to 1 year after liver resection |
| Incidence of incisional hernias | To assess the incidence of incisional hernias in laparoscopic and open left lateral hepatic sectionectomy patients will be contacted at a mean time of 1 year after resection to receive an ultrasound to diagnose incisional hernia. | up to 1 year after liver resection |
| Change of serum glutamic oxalacetic transaminase | Change of serum glutamic oxalacetic transaminase after liver resection.These values will be recorded preoperative, and postoperative day-1,3,5,7. | up to 7 days after liver resection |
| Change of serum glutamic-pyruvic transaminase | Change of serum glutamic-pyruvic transaminase after liver resection.These values will be recorded preoperative, and postoperative day-1,3,5,7. | up to 7 days after liver resection |
| Mortality rates | the rate of postoperative death | up to 30 days after liver resection |
| Operation time(min) | the during of operation | intraoperative |
| Blood loss(ml) | the volume of blood loss | up to 30 days after liver resection |
| Blood transfusion (times and units) | intraoperative blood transfusion | intraoperative |
| C-reactive protein (mg/mL) | C-reactive protein levels on preoperative and postoperative day-1,3,5 | up to 5 days after liver resection |