Metabolic Consequences of Moderate Weight Gain - Role of Dietary Fat Composition (LIPOGAIN)

Metabolic Consequences of Moderate Weight Gain - Role of Dietary Fat Composition (LIPOGAIN): a Randomized Double-Blind Controlled Study

The purpose of this study is to investigate the metabolic consequences of a moderate weight gain and if the type of dietary fat (saturated versus polyunsaturated) can modify the effects in young healthy adults. Hypothesis: the type of dietary fat can modify the effects of weight gain.

Specific goals:

• Investigate if dietary fat composition influences liver fat accumulation and metabolic risk factors in response to moderate weight gain
• Investigate if polyunsaturated fat (PUFA) in the diet could counteract any unfavorable metabolic changes that are expected to accompany moderate weight gain
• Investigate effects of weight gain and dietary fat composition on markers of vascular health

Inclusion Criteria:

• Healthy,
• Body Mass Index 18-27

Exclusion Criteria:

• Liver disease,
• Coronary heart disease,
• Diabetes mellitus,
• Malignant diseases,
• Alcohol or drug abuse,
• Magnetic Resonance-incompatibility,
• Abnormal clinical chemistry,
• Use of drugs that significantly effects energy metabolism,
• Heavy exercise,
• Pregnancy or lactation,
• Allergy of gluten, egg or milk protein