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The purpose of this study is to investigate the metabolic consequences of a moderate weight gain and if the type of dietary fat (saturated versus polyunsaturated) can modify the effects in young healthy adults. Hypothesis: the type of dietary fat can modify the effects of weight gain.
Specific goals:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Saturated fatty acid group | Active Comparator | Addition of saturated fatty acids to the diet inte the form of pastries |
|
| Polyunsaturated fatty acid group | Active Comparator | Addition of polyunsaturated fatty acids to the diet in the form of pastries |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polyunsaturated fatty acid group | Other | Addition of polyunsaturated fatty acids to the diet in the form of pastries |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hepatic steatosis by magnetic resonance tomography (MRT) | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| high density lipoprotein (HDL) | 6 weeks | |
| low density lipoprotein (LDL) | 6 weeks | |
| Insulin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ulf Risérus, Ass. professor | Clinical Nutrition and Metabolism, Dept. of Public Health and Caring Sciences, Uppsala University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uppsala University Hospital, Uppsala Science Park | Uppsala | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33344496 | Derived | Rosqvist F, Orho-Melander M, Kullberg J, Iggman D, Johansson HE, Cedernaes J, Ahlstrom H, Riserus U. Abdominal Fat and Metabolic Health Markers but Not PNPLA3 Genotype Predicts Liver Fat Accumulation in Response to Excess Intake of Energy and Saturated Fat in Healthy Individuals. Front Nutr. 2020 Dec 3;7:606004. doi: 10.3389/fnut.2020.606004. eCollection 2020. | |
| 28275132 |
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| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D015430 | Weight Gain |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
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| Saturated fatty acid group | Other | Addition of saturated fatty acids to the diet in the form of pastries |
|
| 6 weeks |
| Glucose | 6 weeks |
| Triglycerides | 6 weeks |
| Cholesterol | 6 weeks |
| Apolipoprotein B (ApoB) | 6 weeks |
| Apolipoprotein A1 (ApoA1) | 6 weeks |
| Aspartate aminotransferase (ASAT) | 6 weeks |
| Alanine aminotransferase (ALAT) | 6 weeks |
| Gamma glutamyl transpeptidase (GGT) | 6 weeks |
| Homeostasis model of assessment insulin resistance (HOMA-IR) | 6 weeks |
| C-reactive protein (CRP) | 6 weeks |
| Proinsulin | 6 weeks |
| Endostatin | 6 weeks |
| Pentraxin-3 (PTX-3) | 6 weeks |
| Endothelin-1 (ET-1) | 6 weeks |
| E-selectin | 6 weeks |
| Cathepsin-S | 6 weeks |
| Cystatin C | 6 weeks |
| Perfilyev A, Dahlman I, Gillberg L, Rosqvist F, Iggman D, Volkov P, Nilsson E, Riserus U, Ling C. Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial. Am J Clin Nutr. 2017 Apr;105(4):991-1000. doi: 10.3945/ajcn.116.143164. Epub 2017 Mar 8. |
| 25319187 | Derived | Iggman D, Rosqvist F, Larsson A, Arnlov J, Beckman L, Rudling M, Riserus U. Role of dietary fats in modulating cardiometabolic risk during moderate weight gain: a randomized double-blind overfeeding trial (LIPOGAIN study). J Am Heart Assoc. 2014 Oct 15;3(5):e001095. doi: 10.1161/JAHA.114.001095. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |