Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Karolinska Institutet | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Saturated fatty acids (SFA)-group | Experimental | Weight gain created by addition of muffins baked on saturated fat |
|
| Polyunsaturated fatty acids (PUFA)-group | Experimental | Weight gain created by addition of muffins baked on polyunsaturated fat |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PUFA-group | Dietary Supplement |
| ||
| SFA-group |
| Measure | Description | Time Frame |
|---|---|---|
| Change in lean tissue mass | Assessed by magnetic resonance imaging (MRI) and air displacement plethysmography (BodPod) | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in hepatic fat content | Assessed by magnetic resonance imaging (MRI) | 10 weeks |
| Change in visceral adipose tissue (VAT) | Assessed by magnetic resonance imaging (MRI) |
| Measure | Description | Time Frame |
|---|---|---|
| Circulating hormones and molecular analyses in muscle and fat tissue | Serum hormones including prolactin, tyroxin, T3, cortisol, growth hormone, Insulin growth factor-1. Fat cell morphology assessment in fat tissue, and gene and protein expression, DNA methylation analyses in fat and muscle tissue, palmitate tracer uptake in liver using positron emission tomography | 10 weeks |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Ulf Riserus | Uppsala University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uppsala University; Clinical nutrition and metabolism; Dept of public health and caring sciences | Uppsala | Please Select | 75185 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38636844 | Derived | Rosqvist F, Cedernaes J, Martinez Mora A, Friden M, Johansson HE, Iggman D, Larsson A, Ahlstrom H, Kullberg J, Riserus U. Overfeeding polyunsaturated fat compared with saturated fat does not differentially influence lean tissue accumulation in individuals with overweight: a randomized controlled trial. Am J Clin Nutr. 2024 Jul;120(1):121-128. doi: 10.1016/j.ajcnut.2024.04.010. Epub 2024 Apr 16. | |
| 33344496 |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D009765 | Obesity |
| D015430 | Weight Gain |
| D005234 | Fatty Liver |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Dietary Supplement |
|
| 10 weeks |
| Change in total adipose tissue | Assessed by magnetic resonance imaging (MRI) | 10 weeks |
| Change in pancreatic fat | Assessed by MRI | 10 weeks |
| Change in insulin sensitivity | Assessed by oral glucose tolerance test (OGTT) | 10 weeks |
| Change in plasma lipids | Plasma cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, apolipoprotein B, apolipoprotein A1, free fatty acids, glycerol, proprotein convertase subtilisin/kexin type 9 | 10 weeks |
| Change in circulating inflammation and coagulation markers | Plasma tumor necrosis factor-receptor 2, Interleukin receptor 1 antagonist, C-reactive protein, fibrinogen, adhesion molecules | 10 weeks |
| Derived |
| Rosqvist F, Orho-Melander M, Kullberg J, Iggman D, Johansson HE, Cedernaes J, Ahlstrom H, Riserus U. Abdominal Fat and Metabolic Health Markers but Not PNPLA3 Genotype Predicts Liver Fat Accumulation in Response to Excess Intake of Energy and Saturated Fat in Healthy Individuals. Front Nutr. 2020 Dec 3;7:606004. doi: 10.3389/fnut.2020.606004. eCollection 2020. |
| 31369090 | Derived | Rosqvist F, Kullberg J, Stahlman M, Cedernaes J, Heurling K, Johansson HE, Iggman D, Wilking H, Larsson A, Eriksson O, Johansson L, Straniero S, Rudling M, Antoni G, Lubberink M, Orho-Melander M, Boren J, Ahlstrom H, Riserus U. Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized Trial. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6207-6219. doi: 10.1210/jc.2019-00160. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |