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The study hypothesis is that the release of gut hormones is increased proportionally to caloric load in each meal. Three different meals with different meal size will therefore be served and gut hormones determined.
In healthy males and females, meals with 511, 743 and 1034 kcal will be given orally. Samples will be taken during the following 300 min and gut hormones (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1) will be determined along with insulin and glucagon levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy males | Experimental | Meal ingestion in healthy males |
|
| Healthy females | Experimental | Meal ingestion in healthy females |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Meal ingestion | Other | Meal 511 kcal, meal 743 kcal or meal 1034 kcal |
|
| Measure | Description | Time Frame |
|---|---|---|
| Release of gut hormones | 300 min |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin secretion | 300 min |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bo Ahrén, PhD | Lund University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Clinical Sciences Lund, Lund University | Lund | 221 84 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25375983 | Derived | Alsalim W, Omar B, Pacini G, Bizzotto R, Mari A, Ahren B. Incretin and islet hormone responses to meals of increasing size in healthy subjects. J Clin Endocrinol Metab. 2015 Feb;100(2):561-8. doi: 10.1210/jc.2014-2865. Epub 2014 Nov 6. |
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