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The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.
Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oral amino acid mixture | Experimental | Oral administration of amino acid mixture in healthy volunteers |
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| Intravenous amino acid administration | Experimental | Intravenous infusion of amino acid mixture in healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral amino acid mixture | Other | Amino acid mixture 2,93 ml/kg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Gut hormone secretion | 300 min |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin secretion | 300 min |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bo Ahrén, PhD | Lund University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Clinical Sciences Lund, Lund University | Lund | 221 84 | Sweden |
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| Intravenous amino acid administration | Other | Amino acid mixture 2,93 ml/kg |
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