Protein, Amino Acids & Insulin & Glucagon Secretion in Humans

The Effect of Ingestion of Foods on the Plasma Glucose and Insulin Response in Subjects With Type 2 Diabetes: Protein, Amino Acids & Insulin & Glucagon Secretion in Humans

The purpose of this study is to determine the effect of various foods and/or food substances such as fats or proteins on the blood glucose and insulin concentrations in people with and without type 2 diabetes.

Various foods or food substances are given as a test meal. The metabolic response is determined at various times after the administration of the meal (e.g. blood glucose, and other hormones and metabolites).

Inclusion Criteria:

• Subjects with or without type 2 diabetes
• C-Peptide > 1.5 ng/ml
• Able to come to the Minneapolis VA Medical Center on several occasions over 2-4 weeks

Exclusion Criteria:

• Body mass index > 40
• hematologic abnormalities
• liver disease
• kidney disease
• congestive heart failure
• life threatening malignancies