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Cutaneous allodynia is an increased skin sensitivity experienced during a headache. It has been noted in several studies that in patients with migraine, seventy nine percent of the patients experienced allodynia on the facial skin on the same side as the headache. Understanding more about the occurrence of phonophobia (increased sensitivity to sound) and allodynia may help us understand how the pain system works in migraine. It is hoped that the knowledge gained from this trial may enable us to more effectively treat patients with migraine headache.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subjects with episodic migraine with allodynia | These are subjects with episodic migraine with allodynia |
| |
| Subjects with episodic migraine without allodynia | Subjects with episodic migraine without allodynia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sounds | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation Between Phonophobia (Sound Sensitivity) and Allodynia (Skin Sensitivity) in Subjects With Episodic Migraine | Measurement of phonophobia: determine sound aversion threshold (SAT), measured in dB during a migraine attack in subjects with and in subjects without allodynia. | Subjects with or without allodynia return during a migraine attack and are tested for Phonophobia. |
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Inclusion Criteria:
Inclusion criteria for migraine subjects:
Inclusion criteria for control subjects:
Exclusion criteria for migraine subjects:
Exclusion criteria for control subjects:
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Adult women and men with a diagnosis of episodic migraine
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| Name | Affiliation | Role |
|---|---|---|
| Abraham A. Ashkenazi, M.D. | Thomas Jefferson University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jefferson Headache Center | Philadelphia | Pennsylvania | 19107 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20562466 | Result | Ashkenazi A, Yang I, Mushtaq A, Oshinsky ML. Is phonophobia associated with cutaneous allodynia in migraine? J Neurol Neurosurg Psychiatry. 2010 Nov;81(11):1256-60. doi: 10.1136/jnnp.2009.198481. Epub 2010 Jun 20. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Subjects With Episodic Migraine With Allodynia | These are the subjects with episodic migraine with allodynia. |
| FG001 | Subjects With Episodic Migraine Without Allodynia | These are the subjects with episodic migraine without allodynia. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Subjects With Episodic Migraine | Subjects with less than 8 distict migraine episodes per month. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Correlation Between Phonophobia (Sound Sensitivity) and Allodynia (Skin Sensitivity) in Subjects With Episodic Migraine | Measurement of phonophobia: determine sound aversion threshold (SAT), measured in dB during a migraine attack in subjects with and in subjects without allodynia. | Posted | Number | participants | Subjects with or without allodynia return during a migraine attack and are tested for Phonophobia. |
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Subjects With Episodic Migraine |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Abraham A. Ashkenazi, MD-Principal Investigator | Doylestown Hospital | 215-625-2894 | aashkenazi2001@yahoo.com |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D013016 | Sound |
| ID | Term |
|---|---|
| D011840 | Radiation, Nonionizing |
| D011827 | Radiation |
| D055585 | Physical Phenomena |
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| Participants |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
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| 0 |
| 38 |
| 0 |
| 38 |
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| D009422 | Nervous System Diseases |