• Migraine in Electrohypersensitive Patients

  NCT04845152

  CompletedObservationalUpdated Jun 26, 2023
• Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.

  NCT00329771

  CompletedObservationalUpdated Mar 27, 2024
• Pain Processing in Adults With Migraines

  NCT02748577

  CompletedInterventionalNot ApplicableUpdated May 12, 2020
• Presence of Signs of Central Sensitization in Episodic and Chronic Migraine

  NCT05162664

  CompletedInterventionalNot ApplicableUpdated Nov 18, 2023
• Prevalence of Phonophobia and Cutaneous Allodynia in Episodic Migraineurs

  NCT00386880

  CompletedObservationalUpdated Aug 22, 2014
• Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.

  NCT07559565

  Not yet recruitingObservationalUpdated Apr 30, 2026

ClinicalTrials.gov ID

NCT04580641

Lead Sponsor

University Hospital, Clermont-FerrandOTHER

Overall Status

Unknown status

Study Type

Observational

Enrollment

180Estimated

Last Update Posted

Oct 8, 2020Actual

Start Date

Oct 1, 2020Estimated

Primary Completion Date

Jun 2021Estimated

Completion Date

Sep 2021Estimated

Official Title

Allodynia and Sensorial Hypersensitivity in Patients With Migraine: Validation of a Specific Questionnaire

Brief Summary

Migraine is very frequent (15% of the general population). During attacks, many subjects with migraine have allodynia (pain induced by normally non-painful stimuli), photophobia (hypersensitivity to light), phonophobia (hypersensitivity to sound) or osmophobia (hypersensitivity to odours). The goal of the present study is to validate a new questionnaire made of 4 parts evaluating the presence of these 4 types of hypersensitivity, both during or between migraine attacks. It will allow to look for associations of these 4 symptoms and association of hypersensitivity with patients' or migraine's characteristics.

Detailed Description

The prevalence of migraine is around 15% worldwide (GBD 2016, Lancet Neurol 2018). During attacks, and even between attacks, especially when migraine frequency is high, many subjects with migraine present with photophobia, phonophobia, osmophobia or allodynia. These symptoms are though to correspond to central sensitization and can be found in animal models of migraine (Boyer et al., Pain 2017; Dallel et al., Cephalalgia 2018).

These 4 symptoms have been studied separately in previous studies but to date, there is no overall questionnaire evaluating these 4 sub-types of hypersensitivity. The investigators have constituted a questionnaire based on previous validated questionnaires that have been translated into French (Lipton et al., 2008 for cutaneous allodynia; Choi et al., 2009 for photophobia), a previous questionnaire validated in French (Khalfa et al, 2002 for phonophobia) and created a few questions for each of the 4 symptoms, including osmophobia.

• Migraine

• Questionnaire

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Subjects fulfilling 2018 international headache society criteria for migraine.
• Age > 17 years.
• Written consent.

Exclusion Criteria:

• Presence of neurological comorbidities that could lead to sensorial or sensitive abnormalities
• Presence of dermatological comorbidities that could lead to sensorial or sensitive abnormalities
• Presence of ENT comorbidities that could lead to sensorial or sensitive abnormalities
• Significant cognitive dysfunction precluding proper completion of the self-administered questionnaire

Observational Model

Case-Only

Time Perspective

Cross-Sectional

Lead Sponsor

University Hospital, Clermont-FerrandOTHER

promo_interne_drci@chu-clermontferrand.fr0473754963 ext. 33

promo_interne_drci@chu-clermontferrand.fr0473754963 ext. 33

promo_interne_drci@chu-clermontferrand.fr0473754963

promo_interne_drci@chu-clermontferrand.fr0473754963 ext. 33